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KMID : 0608619950050010115
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Korean Journal of Aerospace and Environmental Medicine
1995 Volume.5 No. 1 p.115 ~ p.128
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Experimental Study on the Effect of Combined Administration of Glutathione and L-Ascorbic Acid on the Oxygen Toxicity Tolerance in Rat
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윤덕로
안윤옥/조수헌/유근영/박병주
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Abstract
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Oxygen is an essential element in maintaining life, but it can be harmful in high concentration. Oxygen has be on widely used in management of many respiratory diseases and in also in hypoxic conditions Since 1960's, with introduction of
hyperbaric
oxygen therapy and the development of aerospace and underwater medicine, there has been increasing chances of human exposure to hyperbaric oxygen environment. Thereby oxygen toxicity has become critical medical problems.
This study was designed to examine and evaluate the protective effects of glutathione and L-ascorbic acid to oxygen toxicity.
Seventy five male rats were divided into 5 groups (2 controls 3 experimentals). Control groups were exposed to ambient air (control 1) and 100% oxygen of 5ATA for 120 minutes (control 2). All experintal groups were exposed to 100% oxygen of 5ATA
for
120minutes with administration of glutathione, 8mmoole/kg (experimental group 1). Ascorbic acid. 400mg/kg (group 2) and both in half dosages (group 3)
@ES The results observed are as follows :
@EN 1. The single administration of glutathione or L-ascorbic acid lower mortality rate in respective cases, whereas the combined administration of both drugs revealed showed similar mortality rate with single administration of glutathione alone.
2. With the administraton of glutathione alone or glutathione and L-ascorbic acid together, convulsion was not observed in any rat while in control group, the incidence was 100 percent. When L-ascorbie acid alone was given, however, there was no
significant change in the convulsion rate and the time to the onset of convulsion.
3. The three experimental groups all showed significantly low water content of lung. In brain water content, the glutathione treated group and the grouptreated whth both drugs combined, showed significant decrease, but the ascorbic acid treated
group
did not, show any decrease.
4. In case of the pathological findings of lung, the glutathione administered group and the group of combined treatment of both drugs showed less inflammatory changes, but the ascorbic acid treated group revealed no significant diference.
In cases of the pathological findings of bran, all three groups showed no significant differeces.
5. The combined administration of two drugs in half doses revealed more protective effect than expected. The effect was alomost equal to the full dose treatment of glutathione.
From above results, it can be concluded that the glutathione is very effective against oxygen toxicity, whereas ascorbic acid has less protective effect effect than glutathione. Glutathione seems to complement the antioxidant effect of L-ascorbic
acid.
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